| DATA | Casa | Resultados | Fora | H2H |
| 04 May 17:00 | Memphis 901 | VS | Tampa Bay Rowdies | Histórico |
| 04 May 19:30 | Charleston Battery | VS | Hartford Athletic | Histórico |
| 04 May 20:00 | Loudoun United | VS | Detroit City | Histórico |
| 04 May 20:00 | North Carolina | VS | Rhode Island FC | |
| 04 May 20:00 | Pittsburgh Riverhounds SC | VS | Miami FC | Histórico |
| 04 May 20:30 | Birmingham Legion | VS | FC Tulsa | Histórico |
| 04 May 21:30 | San Antonio FC | VS | Oakland Roots | Histórico |
| 04 May 22:00 | Colorado Springs Switchbacks FC | VS | El Paso Locomotive | |
| 04 May 23:00 | Monterey Bay FC | VS | Indy Eleven | |
| 04 May 23:30 | Las Vegas Lights FC | VS | New Mexico United | Histórico |
| 04 May 23:30 | Phoenix Rising FC | VS | Sacramento Republic FC | Histórico |
| 08 May 20:00 | Miami FC | VS | Memphis 901 | |
| 10 May 20:00 | Loudoun United | VS | El Paso Locomotive | |
| 11 May 18:00 | Detroit City | VS | Phoenix Rising FC | Histórico |
| 11 May 20:00 | Hartford Athletic | VS | Colorado Springs Switchbacks FC | |
| 11 May 20:30 | Louisville City FC | VS | Orange County SC | |
| 11 May 20:30 | Rhode Island FC | VS | Sacramento Republic FC | |
| 11 May 20:30 | Tampa Bay Rowdies | VS | Birmingham Legion | Histórico |
| 11 May 21:30 | FC Tulsa | VS | Pittsburgh Riverhounds SC | Histórico |
| 11 May 21:30 | San Antonio FC | VS | Las Vegas Lights FC | |
| 11 May 22:00 | New Mexico United | VS | Oakland Roots | Histórico |
| 11 May 23:00 | Monterey Bay FC | VS | Memphis 901 | Histórico |
| 12 May 20:00 | Miami FC | VS | Indy Eleven | Histórico |
| 14 May 20:00 | North Carolina | VS | Loudoun United | |
| 15 May 21:00 | Birmingham Legion | VS | Charleston Battery | Histórico |
| 17 May 22:00 | Colorado Springs Switchbacks FC | VS | Rhode Island FC | |
| 17 May 22:00 | El Paso Locomotive | VS | Memphis 901 | Histórico |
| 18 May 20:00 | Indy Eleven | VS | Hartford Athletic | Histórico |
| 18 May 20:00 | Loudoun United | VS | Monterey Bay FC | |
| 18 May 20:00 | Pittsburgh Riverhounds SC | VS | North Carolina | |
| 18 May 20:30 | Tampa Bay Rowdies | VS | FC Tulsa | Histórico |
| 18 May 23:00 | Oakland Roots | VS | Orange County SC | Histórico |
| 18 May 23:30 | Las Vegas Lights FC | VS | Louisville City FC | Histórico |
| 18 May 23:30 | Phoenix Rising FC | VS | Miami FC | Histórico |
| 24 May 20:30 | Charleston Battery | VS | El Paso Locomotive | Histórico |
| 24 May 20:30 | Hartford Athletic | VS | Monterey Bay FC | |
| 24 May 21:30 | FC Tulsa | VS | Oakland Roots | Histórico |
| 25 May 17:00 | Rhode Island FC | VS | Louisville City FC | |
| 25 May 20:00 | Indy Eleven | VS | Phoenix Rising FC | Histórico |
| 25 May 20:00 | Miami FC | VS | North Carolina | |
| 25 May 20:30 | Tampa Bay Rowdies | VS | Las Vegas Lights FC | Histórico |
| 25 May 21:30 | Memphis 901 | VS | Pittsburgh Riverhounds SC | Histórico |
| 25 May 22:00 | New Mexico United | VS | San Antonio FC | Histórico |
| 25 May 23:00 | Orange County SC | VS | Loudoun United | Histórico |
| 25 May 23:00 | Sacramento Republic FC | VS | Birmingham Legion | Histórico |
| 29 May 20:30 | Louisville City FC | VS | Detroit City | Histórico |
| 29 May 23:00 | Monterey Bay FC | VS | Charleston Battery | |
